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Showing results for M. S. tavazoie
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HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events.
Alarcón CR, Goodarzi H, Lee H, Liu X, Tavazoie S, Tavazoie SF. Alarcón CR, et al. Cell. 2015 Sep 10;162(6):1299-308. doi: 10.1016/j.cell.2015.08.011. Epub 2015 Aug 27. Cell. 2015. PMID: 26321680 Free PMC article.
We find that the RNA-binding protein HNRNPA2B1 binds m(6)A-bearing RNAs in vivo and in vitro and its biochemical footprint matches the m(6)A consensus motif. ...Also, HNRNPA2B1 loss and METTL3 depletion cause similar processing defects for these pri-miRNA precursors …
We find that the RNA-binding protein HNRNPA2B1 binds m(6)A-bearing RNAs in vivo and in vitro and its biochemical footprint matches th …
N6-methyladenosine marks primary microRNAs for processing.
Alarcón CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF. Alarcón CR, et al. Nature. 2015 Mar 26;519(7544):482-5. doi: 10.1038/nature14281. Epub 2015 Mar 18. Nature. 2015. PMID: 25799998 Free PMC article.
In vitro processing reactions confirmed the sufficiency of the N(6)-methyladenosine (m(6)A) mark in promoting pri-miRNA processing. Finally, gain-of-function experiments revealed that METTL3 is sufficient to enhance miRNA maturation in a global and non-cell-type-specific m …
In vitro processing reactions confirmed the sufficiency of the N(6)-methyladenosine (m(6)A) mark in promoting pri-miRNA processing. F …
Learning module networks from genome-wide location and expression data.
Xu X, Wang L, Ding D. Xu X, et al. FEBS Lett. 2004 Dec 17;578(3):297-304. doi: 10.1016/j.febslet.2004.11.019. FEBS Lett. 2004. PMID: 15589836 Free article.
Natl. Acad. Sci. USA 95, 14863-14868; Tavazoie, S., Hughes, J.D., Campbell, M.J., Cho, R.J. and Church, G.M. (1999) Nat. Genet. 22, 281-285; Ihmels, J., Friedlander, G., Bergmann, S., Sarig, O., Ziv, Y. and Barkai, N. (2002) Nat. Genet. 31, 370- …
Natl. Acad. Sci. USA 95, 14863-14868; Tavazoie, S., Hughes, J.D., Campbell, M.J., Cho, R.J. and Church, G.M. (19 …
[Prediction of transcription and genomic sequences].
Martin D, Ghattas B, Thieffry D. Martin D, et al. Med Sci (Paris). 2004 Nov;20(11):1036-40. doi: 10.1051/medsci/200420111036. Med Sci (Paris). 2004. PMID: 15525501 Free article. Review. French.
On the basis of the resulting sequences, computational biologists now attempt to localise the most important functional regions, starting with genes, but also importantly the regulatory motifs and conditions controlling their expression. In a recent paper published in Cell, M …
On the basis of the resulting sequences, computational biologists now attempt to localise the most important functional regions, starting wi …
let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts.
Legesse-Miller A, Elemento O, Pfau SJ, Forman JJ, Tavazoie S, Coller HA. Legesse-Miller A, et al. J Biol Chem. 2009 Mar 13;284(11):6605-9. doi: 10.1074/jbc.C900002200. Epub 2009 Jan 6. J Biol Chem. 2009. PMID: 19126550 Free PMC article.
We hypothesized that low Cdc34 levels would result in decreased SCF activity, stabilization of the SCF target Wee1, and G(2)/M accumulation. Consistent with this hypothesis, small interfering RNA-mediated down-regulation of Wee1 reversed the G(2)/M phenotype induced …
We hypothesized that low Cdc34 levels would result in decreased SCF activity, stabilization of the SCF target Wee1, and G(2)/M accumu …